Subcutaneous administration of parenteral drugs
DISEASE	INTERVENTION	COMPARISON	RESULTS
J Antimicrob Chemother. 2025 Nov 12:dkaf381. doi: 10.1093/jac/dkaf381. Epub ahead of print.		Clinical Trial (non-controlled, non-randomized)
IN antibiotics, amoxicillin/clavulanic, subcutaneous administration, clinical pharmacology	The Use of subcutaneous (SC) administration of amoxicillin/clavulanic acid As Treatment, Acute	Is equal Than intravenous (IV) administration of amoxicillin/clavulanic acid	To achieve similar trough concentrations at 5h post-administration. Cmax values were ∼45% lower with SC. Only 3 patients in SC group. Local SC adverse events: transient oedema, erythema and pain
Forum Infectious Diseases. 2025 Jun;12(6):ofaf313, doi: 10.1093/ofid/ofaf313		Clinical Trial (non-controlled, non-randomized)
IN antibiotics, cephalosporins, ceftriaxone, subcutaneous administration, clinical pharmacology	The Use of administering ceftriaxone as subcutaneous, same doses As Treatment, Acute	Is equal Than administering it intravenously	To achieve similar bioavailability (99%), concentrations and good probability of target attainment
Infect Dis Now. 2025 Dec 11;56(2):105232. doi: 10.1016/j.idnow.2025.105232. Epub ahead of print		Consensus, Guideline
IN antibiotics, various, subcutaneous administration, clinical pharmacology	The Use of subcutaneous (SC) administration of ceftriaxone, Cefazolin, ertapenem, meropenem, piperacillin–tazobactam, temocillin, and benzathine benzylpenicillin. Possible also for teicoplanin, amoxicillin, amoxicillin–clavulanic acid, ceftazidime and daptomycin As Treatment, Acute	Is equal Than intravenous (IV) administration of same drugs	To achieve similar trough concentrations and clinical effectiveness. Pic concentrations (Cmax) are lower, however, and local reactions and hematome are frequent adverse events
Eur Heart J Cardiovasc Pharmacother. 2025 Feb 8;11(1):94-104. doi: 10.1093/ehjcvp/pvae083		Systematic Review
IN diuretics, furosemide, subcutaneous administration, clinical pharmacology	The Use of subcutaneous furosemide, specially new pH-neutral preparations of subcutaneous furosemide As Treatment, Acute	Is equal Than conventional intravenous furosemide	To achieved similar diuresis, natriuresis, and bioavailability. SC conventional furosemide was associated with substantial skin irritation (3-23% of patients)